Core Controversy over origin-tracing of the SARS-CoV-2: Who Is Conducting the Virus GOF Research?

Qin An Strategy Study

1.Who is conducting the gain-of-function (GOF) research is the focal point of China-US argument on the artificially synthesized novel coronavirus.

The United States is now shirking the responsibility of the novel coronavirus origin to China, framing China for performing the coronavirus GOF research in its Wuhan Institute of Virology. The key point of the question now is that, the one performs the GOF research will be the lab creator of the novel coronavirus. Now, as long as it can be proved that the United States has conducted the recombinant coronavirus GOF research, we will confirm that the US virus laboratory is the prime culprit in creating the SARS-CoV-2.

According to the report of New York Times on June 14, Shi Zhengli, a researcher at the Wuhan Institute of Virology of the Chinese Academy of Sciences, told the New York Times a few days ago that her experiment was different from the “gain-of-function” (GOF) study because she did not intend to make the virus more dangerous, but to understand how the virus spreads across species.

Shi Zhengli, known as the bat girl, once led a virus expedition into domestic caves to collect samples from bats and bird droppings, so as to understand how the virus was transmitted from animals to human. The Wuhan Institute of Virology helped find bats in the wild, search for bat coronavirus strains. They did hard work for the United States to collect coronavirus strains and perform genetic sequencing. From 2015 to 2019, the National Institutes of Health (NIH), the United States distributed 3.7 million U.S. dollars of scientific research funding to the EcoHealth Alliance, a non-profit organization, for the research on bat coronaviruses, which once cooperated with the Wuhan Institute of Virology. Thus part of the 3.7 million U.S. dollars funded by the U.S. government went to the Institute.

A grant of approximately 600,000 U.S. dollars was provided to Wuhan Institute of Virology through the EcoHealth Alliance for a period of 5 years, according to Fauci. Its purpose was to study the relationship between animals and human, conduct monitoring, and determine whether these bat viruses are capable of infecting human or spreading to human. The total fund was renewed during Trump’s term in July 2019. Later, Trump instructed the National Institutes of Health to notify the EcoHealth Alliance in mid-April 2020 that it would stop distributing the remaining fund of around 370,000 U.S. dollars this year. Pete Daszak, chairman of the EcoHealth Alliance, told the National Public Radio (NPR) that the suspension of funding has brought significant losses to U.S. scientific research projects; as they were unable to obtain much coronavirus samples from the Wuhan Institute of Virology .

In addition, the U.S. Agency for International Development (USAID) once funded 550,000 U.S. dollars through the EcoHealth Alliance to the Wuhan Institute of Virology for the PREDICT project, which is part of the Emerging Pandemic Threats (EPT) program funded by the USAID. From April 2008 to September 2018, at least tens of thousands of coronaviruses from animals, including bats, were transported from China to laboratories in the United States to help the U.S. government and scientific research organizations establish the coronavirus gene pool.

With the help of EcoHealth Alliance, the United States has cooperated with scientific research institutions in more than 25 countries to study origins of new coronavirus-like viruses during the past 20 years, which have become an integral part of the U.S. coronavirus gene pool. When coronavirus samples were collected by the team of Peter Daszak, chairman of the Eco-Health Alliance, they would be stored in liquid nitrogen and sent to partner laboratories in the United States for analysis. Therefor the U.S. viral gene pool was established.

“NO GOF research for enhancement of viral toxicity have ever been performed or collaborated in my laboratory!” insisted Shi Zhengli. Her words are the key to confirm that the Wuhan Institute of Virology, China has never conducted a coronavirus GOF research!

Dr. Fauci denied that the United States had funded the controversial GOF research of the Wuhan Institute in the U.S. Congress testimony on May 12, 2021. It was also truth because the method to create chimeric virus required for GOF research was invented with an exclusive patent of Professor Ralph S. Baric, and is protected by patents.

Professor Ralph S. Baric’s team holds the most authoritative interpretation power and the most advanced chimeric virus creation ability among all scientists. As some of its patents are world patents, scientists are supposed to apply to the team and pay for the patent if they generate such demand during the virus research process. It is believed that Wuhan Institute of Virology should have no patent use records, nor the ability and technology to perform the research. The chimeric virus creation is a relatively complicated process, and the professional technology and professional software applied in the process are peculiar to the team. In addition, assistive software, gene comparison equipment, and big data platform that are helpful for the chimeric technology are also peculiar to the United States, and anyone else using them should be authorized and leave a record.

Therefore, if there are chimeric virus products that are not authorized by the United States in the world, the chimeric process must have taken place in the United States, to be specific,in Professor Baric’s laboratory or the laboratory in Fort Detrick with the same patent use rights and graduate students of Prof. Baric working in it. This proves that the laboratory created novel coronavirus must be from the United States.

In an interview with CNN on April 26, President of the U.S. EcoHealth Alliance, as well as a virus hunter, Dasak said that the Wuhan Institute of Virology had not yet possessed the virus that caused the COVID-19 epidemic. Only close relatives of the virus, not itself, were founded, so it is impossible that the virus originated from the Wuhan Institute.

After the global outbreak of the COVID-19, the United States attributed the virus origin to the Wuhan P4 laboratory. However, Hervé RAOUL, director of the French Lyon P4 laboratory who helped build the Wuhan P4 laboratory, said on April 20, 2020 that the P4 laboratory do not usually study coronaviruses. Generally speaking, the viruses tested in the P4 laboratory are usually more active and deadlier, such as Ebola virus, Lassa virus, and Marburg virus. Coronavirus has never been studied.

All research on the coronavirus in France is conducted in the P3 laboratory, which also proves that the leak of coronavirus happened in Wuhan P4 laboratory is a lie! On the contrary, the above research on the SARS-like coronavirus cross-species infection of mice and human studied by the U.S. virologists in 2015 and 2016 happened to be in the BSL-3 laboratory of the University of North Carolina, the United States. Yuan Zhiming, a researcher at the Wuhan Institute of Virology, CAS, and director of the Wuhan National Biosafety Laboratory, said that the institute “has no intention and does not have the ability to design and create a new coronavirus”.

2. The United States has a history of conducting GOF research

The United States has been engaged in virus GOF research. Among them, an avian influenza virus modification experiment has aroused huge controversy. In 2011, the team of Yoshihiro Kawaoka, a professor of virology at the University of Wisconsin-Madison, the United States, and Ron Fouchier, a researcher at the Erasmus Medical Center, the Netherlands, led their team respectively to modify the H5N1 virus with the genetic technology, and found that the modified virus can transmit through the air more easily among ferrets, mammals that are close to human. Relevant experiments can make the H5N1 avian influenza virus more easily to spread between mammals, which is considered to bring the risk of human-to-human transmission.

American critics believe that once this virus with stronger transmission ability is leaked, people will face huge security risks. The National Science Advisory Board for Biosecurity (NSABB) once required that relevant papers should not be published. The World Health Organization also held a meeting on this issue, and related research was temporarily suspended. In October of that year, the United States suspended a number of virus modification projects, including the avian influenza virus modification experiment.

While supporters of biological scientists believe that such experiments will improve the understanding of the avian influenza virus and help deal with the possible natural variants of the avian influenza virus. After multilateral consultations, the British journal Nature and the American journal Science successively published related papers in 2012, and related research was resumed in 2013.

According to an exclusive report on the website of Science journal on February 8, 2019, a committee of the U.S. Department of Health and Human Services “quietly” approved the restart of the experiment last year after the of relevant experiment was suspended for more than four years. “A U.S. government review panel quietly approved experiment applications submitted by two laboratories last year. Such research was considered too dangerous, and federal officials issued a rare moratorium.” The report said. The article stated that one of the experiment projects has been funded by the National Institute of Allergy and Infectious Diseases (NIAID) and “will be launched in a few weeks”. Another experiment project is awaiting funding. In December 2017, the National Institutes of Health lifted relevant funding ban.

3. The United States has concealed the fact of completed GOF research

While the United States is now accusing the Wuhan Institute of Virology of the so-called laboratory virus leaking, it has always failed to provide actual evidence to prove that the Wuhan Institute of Virology conducted GOF research. Instead, it has been concealing the fact that the United States has already performed GOF research! What is it up to? It is to hide the fact that the novel coronavirus actually came from the biochemical weapon genetic engineering project of the BSL-3 laboratory of the University of North Carolina, the United States!

The public conclusive evidence is that U.S. virologists headed by Ralph S.Baric, director of the Department of Epidemiology at the University of North Carolina at Chapel Hill, conducted a recombinant coronavirus GOF research. Research content. The US coronavirus gene pool from all over the world made it possible for Professor Ralph S. Baric, father of the coronavirus in the U.S. and the director of the Department of Epidemiology at the University of North Carolina at Chapel Hill, to collect all the coronavirus samples from China and other parts of the world.

On this basis, Ralph S. Baric successfully conducted the recombinant coronavirus GOF research. The successful experiment results were published on internationally renowned scientific journals, to be specific, two scientific papers on SARS-like Coronavirus GOF research including “A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence” in 2015, and “SARS-like WIV1-CoV poised for human emergence” in 2016.

Moreover, the U.S. government, the U.S. virologist group and the U.S. media have always been concealing Ralph S. Baric, the chief U.S. coronavirologist, as well as the recombinant coronavirus GOF research that he was engaged in! The leaked email quoted also demonstrates that the chairman of EcoHealth Alliance, Peter Daszak, sent a letter to Ralph S. Baric, the chief coronavirologist at the University of North Carolina. Dasazak wrote that Prof. Baric should not join the 27 scientists to publish on scientific journal The Lancet, claiming that the novel coronavirus came from nature, so as not to draw outside attention to his novel coronavirus GOF research.

Christopher Park, an official in charge of biological policy at the State Department, warned not to mention any research that might refer to the United States itself on “GOF”.

On March 30, 2020, (Prague) Czech molecular biologist Dr. Soňa Peková explained in detail why she believes that the novel coronavirus originated from laboratories in the United States, not in China. She also tried to refute the claims published on the journal Nature Medicine that the virus evolved from natural mutation. In an interview with the Czech news channel TA3, she discussed the origin of COVID-19 and explained to the host in detail that it originated from American laboratories rather than nature.

In her research, she found that the RNA control center of COVID-19 was artificially inverted and can operate normally. From the perspective of a biologist, it seems like someone has invaded this RNA control room, turned it over, and cleared all the extra parts in an incredible way to make the function clear. In the interview, she also mentioned that the United States has ordered all American scientists to deny all reports that the virus comes from of US biological laboratories. Meanwhile, the US government urged scientists to write counter-analysis to refute allegations from China. With these efforts, all conflicting information with COVID-19 originating from the laboratory turns into our intervention in crisis management.

According to a report of nearly 12,000 words recently published by the US magazine Vanity Fair, Thomas DiNanno, the former acting assistant secretary of the Bureau of Arms Control, Verification and Compliance (AVC) within the US Department of State, wrote in an internal US government memo that staff of the U.S. Department of State warned internal leaders not to investigate the origin of the novel coronavirus, otherwise they might “open a can of worms”. It has been reported that a total of four former officials of the Department of State said they had been warned not to investigate the origin of the novel coronavirus. They should be afraid of setting themselves on fire! If the investigation continues, we will go straight down to the real origin of the novel coronavirus, namely, the BSL-3 laboratory at the University of North Carolina, including the chief virologist Ralph S. Baric and Biochemical Laboratory in Fort Detrick .

Robert Redfield, then director of the Centers for Disease Control and Prevention (CDC), said in an interview that he received death threats from some famous scientists after expressing his support for the investigation of the “leaking theory” in March this year. “I expected it to come from politicians, not from scientists,” he said.

According to CNN, as early as on February 7, 2020, Trump had told Woodward, the American investigative reporter who revealed the “Watergate Scandal”, that the novel coronavirus is “deadly stuff” and its its lethality is much more serious than severe seasonal flu. When he met Woodward again on March 19, Trump confessed, “I have always wanted to play it down, and I still like playing it down, because I don’t want to create a panic.” However, his decision to play it down for election. The threat of the US resulted in a further loss of control of the epidemic in the United States.

4. Scientific evidence for the development of the novel coronavirus in the U.S.

Most of the research in Ralph S. Baric’s laboratory is based on the model of coronavirus, and invloves the genetic fields of RNA virus transcription, replication, persistence, and cross-species transmission. The University of North Carolina, founded in 1789, is the earliest public university in the United States. The University of North Carolina at Chapel Hill is famous for its biology majors. So far, SRAS2.0 from the University ranks sixth among the top ten viruses and bacteria created by global laboratories.

1) Ralph S. Baric holds the patent for artificial synthesis of virus genes with patent protection:

The so-called “Father of Coronavirus” Ralph Baric at the University of North Carolina should be regarded as a scientific kook who lacks the constraints of scientific ethics! A mixture of genius and scientific kook! What a typical American image! His research papers often study from the point of viruses, so there is a hidden risk of losing control in human society! There have already been cult “human cloning” incident occurred in the U.S. laboratory. Baric has studied coronavirus for decades, and has been committed to the research of gene recombination and chimerism of various coronavirus RNAs for the past over ten years, and has conducted research on artificially recombinant coronavirus infecting human, and publish scientific papers (The Ralph S. Baric research team participated in the research on recombinant coronavirus infecting human in 2016, named SARS-like WIV1-CoV poised for human emergence. The artificially synthesized coronavirus is transformed into a type that can infect people from mice. The research team this time are all American scientists.)

Ralph S. Baric already possesses the most advanced core technology for recombinant coronavirus in the world! He has recombinant gene editing technology and patent protection for coronavirus recombination methods: we inquired that, Ralph Baric has applied for multiple patent protections for coronavirus recombination methods. Among them, the patent No. US9884895-Methods and compositions for chimeric coronavirus spike proteins, was applied for in 2015; while the patent No. US7279327B2 is the Methods for producing recombinant coronavirus. It is written as follows: The present invention relates to methods of producing recombinant nidovirus vectors, particularly coronavirus vectors, and expressing heterologous genes from said vectors. Therefore, the gene editing technology is only mastered by a few US scientists, and protected by patent! Cannot be applied by others! However, the personnel of Fort Detrick, Maryland, the United States are listed as co-inventors, which is more conducive to the covert sharing of patents, and the staff of the Fort Detrick laboratory do not need to pay for the patent in future recombinant virus preparations. Therefore, the BSL-3 laboratory at University of North Carolina has a close relationship with the Fort Detrick laboratory! They can be regarded as an integral whole! It is a military-civilian integration research program.

The U.S. military can modify and develop viruses for biological weapons research through this patent without obtaining an authorization; while Baric grants patent authorizations to military laboratories in exchange for military research funding via the EcoHealth Alliance. Since 2013, the U.S. Department of Defense has funded 39 million U.S. dollars, all of which applied for the genetic engineering project of biochemical weapons in the BSL-3 laboratory of the University of North Carolina in the United States! The artificial cultivation of the novel SARS virus should be part of the biological weapon research and development project of the Department of Defense.

2) Ralph S. Baric is capable of artificially synthesizing viruses:

The chief scientist, Ralph S. Baric of the Ralph S. Baric’s laboratory, with Vanderbilt University and the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID, located at the Biochemical Laboratory in Fort Detrick) as early as the end of the SARS epidemic in 2003, jointly developed a set of reverse genetic cloning platform for the synthesis of the entire gene sequence of the SARS virus. The full-length cDNA clone of MERS virus was first synthesized through this method when MERS broke out in 2013, and the technology then became the core platform for subsequent major virus transformation projects. Its biggest feature is to construct a virus clone artificially based on only the gene sequence of the virus.

Ralph S. Baric has all SARS virus samples. He is an expert on SARS and the father of the coronavirus. He published “Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirus” in 2003, implying that he has been able to replicate the SARS virus indefinitely since then. Soon after the outbreak of SARS in 2003, Ralph received a grant from NIH (National Institute of Health) called “SARS Reverse Genetics” for the study of replication and mutation of SARS virus. The project started in 2004.

3) The GOF research on SARS-like coronaviruses conducted by Ralph S. Baric:

Ralph S. Baric combined the S protein of SHCO14-CoV circulating in Chinese horseshoe bats with the SARS-CoV backbone adapted to mice to form the SHC014-MA15 chimeric virus, and successfully carried out two GOF experiments on SARS-like coronavirus infectiong mice and humans. The successful experiment results were published on internationally renowned scientific journals, to be specific, two scientific papers on SARS-like Coronavirus GOF research including “A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence” in 2015, and “SARS-like WIV1-CoV poised for human emergence” in 2016.

The key controversy of this study is that although the SHC014-CoV circulating in Chinese horseshoe bats can infect human cells, it is not sufficiently virulent to cause disease. After being chimerized with SARS-CoVMA15, which can cause disease in mice, the novel SHC014-MA15 recombinant virus can not only infect human cells, but also cause disease. In other words, if bats carry this novel recombinant virus, they can directly infect people without passing through an intermediate host and make people sick. The GOF research project in the United States is the same as the current COVID-19 in infection mechanism: the S protein binds to the human ACE2 receptor to infect human cells, and the virus has a strong replication ability in human cells and is toxic. In addition, it directly infects without going through an intermediate host!

The artificial cultivation of the novel SARS virus and the virus GOF research should also be part of the biological weapon research and development project of the Department of Defense. Using the SARS coronavirus skeleton and the surface protein of the SHC014-CoV circulating in Chinese horseshoe bats for engineering modification, a hybrid coronavirus was created in the laboratory. European scientists published papers proving the complete function of the yeast-based synthetic genomics platform, which can be applied for gene reconstruction of a variety of RNA viruses, such as the recombination of the coronavirus family.

4) Recombinant coronavirus GOF research funding comes from the United States, and the US government approved the recombinant coronavirus GOF research.

The series of SARS-like coronavirus cross-species infection experiments hosted by the Ralph S. Baric US research team is mainly supported by the National Institute on Aging (NIA), National Institute of Health (NIH), the EcoHealth Alliance (ZLS), and the University of North Carolina. They are financially supported by rewards with the following project numbers: U19AI109761(R.S.B.), U19AI107810(R.S.B.), AI085524 (W.A.M), F32AI102561 (V.D.M), and K99AG049092 (V.D.M) project was funded by National Institute of Allergy and Infectious Diseases (NIAID) and National Institute on Aging (NIA) of the National Institutes of Health (NIH); the human airway epithelial cell culture project was funded by the the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the National Institutes of Health (NIH), through No. DK065988 (S.H.R).

However, the National Institutes of Health (NIH) issued the following statement: “Before the suspension of funding for the GOF research, the experiment of the full-length and chimeric SHC014 recombinant virus has been initiated and conducted, and it has since been reviewed and approved by the National Institutes of Health (NIH). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.” The last two sentences constitute the disclaimer of the National Institutes of Health. At the same time, it also clearly proves that the National Institutes of Health has approved the gain-of-function research on recombinant coronavirus. This is a fact that cannot be concealed by the U.S. government and media!

5) Comments from American bioscientists on the virus GOF research conducted in the United States:

Professor Francis Boyle of Indiana University, who drafted the Biological Weapons Anti-Terrorism Act of 1989, recognizes the SHC014 recombinant virus and 2019-nCoV by Ralph S. Baric and Menachery et al. as “an offensive biological warfare agent, and the gain-of-function mutation (GOF) technology has no legitimate scientific or medical use.”

Professor Boyle’s duty is to oversee biological warfare in the United States. According to Boyle, gain-of-function mutation (GOF) is a DNA genetic engineering technology that can “turbocharge” dangerous biological warfare substances or pathogens. On the Alex Jones Show, he talked about 12 U.S. war bases with many biosafety level 3\biosafety level 4 (BSL3\BSL4) laboratories specializing in system engineering of biological warfare weapons. One of them is the Biosafety Level 3\Biosafety Level 4 (BSL3\BSL4) War Lab in Fort Chapel Hill, North Carolina.

After the leak accidents in Fort Detrick in 2019, a novel coronavirus (COVID-19)-like outbreak occurred in July 2019, with approximately 20,000 people died and 75% of the nearby residents were infected. Then the license was revoked. Professor Francis Boyle of Indiana University, who drafted the Biological Weapons Anti-Terrorism Act of 1989, condemned Fort Detrick, North Carolina for violating the Biological Weapons Act of 1989 he drafted. He believes the Fort Detrick laboratory “turbocharged” all pathogens including SARS coronavirus and MERS coronavirus. He insisted on closing Fort Detrick and conducting a comprehensive investigation on the researchers.

6) The relationship between Ralph S. Baric and the U.S. military:

Professor Baric’s team not only receives long-term research funds from the US military, provides research services for the Fort Detrick Military Biological Weapons Research Base, but also shared the patented technology developed by its own BSL-3 laboratory at the University of North Carolina to the U.S. military, which can also be regarded as the biological weapons project of the military-civilian integration company of the United States biological warfare.

Such approach will send the latest scientific research results to the war machine, which can conduct biological weapon research with the help of the technology and personnel obtained in the process, resulting in a humanitarian crisis. With the knowledge that the U.S. military has a long-term biological weapon R&D program, Professor Baric not only failed to strictly observe scientific ethics and morality, but also provided the virus chimerism method that was originally applied to benefit mankind to the U.S. military biological weapons laboratory, which is a shameful act of the scientific community.

The same group of the U.S. virologists led by Baric also participated in the successful research of Gilead’s anti-coronavirus drug Remdesivir in 2017. It now appears that Remdesivir is indeed effective against the COVID-19. The then U.S. President Trump took the drug Remdesivir on the same day after infection with the novel coronavirus. As a result, he recovered within three days and worked in public! Since that the epidemic in India has broken out, the price of Remdesivir has become reletively high there.

According to Chen Peizhe, academician of Academia Sinica, Taiwan and a vaccine review expert of the “food and drug administration department” in Taiwan, for elderly COVID-19 patients with diabetes or kidney disease, the use of Remdesivir can reduce the mortality rate by 50~60%. Remdesivir is priced at 1,500 U.S. dollars per dose in Taiwan; and now they are preparing to import the high-priced anti-coronavirus drug Remdesivir developed by Baric in mid-June. Whereas the United States Gilead Company has a military background. Rumsfeld, Secretary of Defense of the George W. Bush . administration was the chairman of Gilead Company. Gilead is also regarded as an US military-civilian integration company, helps the United States develop biological weapons.

5.Strong evidence that Baric continues the GOFresearch

In 2014, the Obama government suspended new funding for all GOF research projects that could make influenza, Middle East Respiratory Syndrome, or SARS virus more toxic or contagious. In 2014, the U.S. government announced to prohibit the federal government from funding the gain-of-function research that would increase the virulence of SARS, MERS, or influenza viruses, enhance their transmission capabilities, or expand the range of host species on the grounds that they might accidentally loss control and cause the epidemic. Baric was deeply dissatisfied with this and wrote long to the National Institutes of Health, stating that this restriction will severely affect coronavirus research. If there is another outbreak in the future, the response speed of scientists and control temp of the epidemic may be slowed down. After that, Baric’s ongoing GOF research on the coronavirus was still allowed to continue. He continued the GOF research in including 2015 and 2016. Vanity Fair reported that a footnote showed exemptions for items “critical to the protection of public health or national security”.

6.The U.S. EcoHealth Alliance and Baric have a history of manipulating bat SARS-like coronavirus genes

Just a few weeks before the first novel coronavirus case report in Wuhan in December 2019, Peter Daszak, the chairman of the Alliance talked about it in a podcast interview in Singapore. “You can easily manipulate it (coronavirus) in the laboratory,” said Daszak, “The spike protein has promoted a lot of research on coronaviruses, which poses the risk of zoonotic diseases. You can get sequences and construct proteins. We work with Ralph Baric at the University of North Carolina to insert the backbone of another virus and do some work in the laboratory.”

Conclusion: The above is the scientific proof of the SARS-like coronavirus GOF research conducted by the U.S. virologists headed by Ralph Baric at the University of North Carolina! It is no doubt that the novel coronavirus came from the U.S. virus laboratory, including the BSL-3 laboratory at the University of North Carolina and the chief scientist Ralph S. Baric, as well as the US Army Biochemical Laboratory in Fort Detrick! This is the scientific evidence and counterattack weapon for China against the U.S. smear on the issue of the COVID-19 origin!

 

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